Because of the way your spine is designed, abnormal spinal function can rub, pinch, irritate or choke the delicate tissues of the spinal cord and nerve roots. Neuropathophysiology Abnormal nervous system function While commonly associated with spinal problems, the pinched nerve (compressed lesion) is actually quite rare. Researchers suggest that only 10% to 15% of spinal-related problems are caused by direct pressure of bone on nerve tissue. More frequently, nerves are irritated (facilitative lesion) by improperly functioning spinal structures. This is caused when nerve tissue is stretched, twisted or irritated by malfunctioning spinal curves. Nervous system impairment can affect the tissues, organs and systems of the body, increasing the susceptibility of disease and ill health. Muscles that support the spine are affected too... Myopathology Histopathology Pathophysiology Suggestions to follow during spinal correction.